Decoding the therapeutic potential mechanism of <i>Cornus officinalis</i> in Parkinson's disease: a network pharmacology insight.

ABSTRACT:

Background

Cornus officinalis, traditionally used for its kidney-tonifying and waist-protecting properties, has recently shown potential therapeutic effects in neurological disorders. However, its mechanisms in Parkinson's disease (PD) remain unclear.

Methods

This study employed a network pharmacology approach combined with molecular docking to systematically explore the active components of Cornus officinalis and their associated signaling pathways in PD.

Results

A total of 11,663 PD-related targets were identified from multiple databases, with 185 overlapping targets obtained from active components of Cornus officinalis using SwissTargetPrediction. Protein-protein interaction (PPI) network analysis identified EGFR, TP53, HIF1A, ESR1, PPARG, TNF,

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12702959 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature