Regenerative potential of nanoenabled collagen-polylactide scaffolds for osteochondral defect repair in rabbits.

ABSTRACT: Current tissue engineering strategies for treating traumatic or degenerative cartilage defects in osteoarthritis (OA) remain insufficient in promoting robust tissue regeneration while simultaneously addressing inflammation, matrix degradation, and post-surgical infections. In this study, we evaluated the in vivo biocompatibility and regenerative potential of a nanoenabled collagen-polylactide (Col-PLA) scaffold functionalized with tri-combinatorial nanoemulsions delivering ibuprofen (anti-inflammatory), batimastat (BB-94, anti-proteolytic), and mupirocin (anti-bacterial). Using a femoral osteochondral defect model in New Zealand White rabbits, regeneration was assessed at 4- and 12-week post-implantation by macroscopic scoring, biomechanical indentation mapping, and histological ana

SUBMITTER: Schroter L 

PROVIDER: S-EPMC12702961 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature