Impaired Cardiorespiratory Fitness in Type 1 Diabetes Is Associated With Metabolic Inflexibility and Specific Factors According to Sex.

ABSTRACT:

Background

People with long-term type 1 diabetes have reduced cardiorespiratory fitness (CRF). We aimed to assess the influence of body composition, energy substrate use, and blood glucose control on cardiopulmonary exercise test performance in subjects with uncomplicated, long-term type 1 diabetes.

Methods

Observational, cross-sectional study. Subjects with and without type 1 diabetes, paired by sex and age, underwent treadmill cardiopulmonary exercise test, bioelectrical impedance analysis, indirect calorimetry at rest and during exercise. We used the t-pair test; multivariate linear regression models and mediation analysis were used to evaluate determinants of CRF.

Results

54 cases and 54 controls (52% female) were evaluated. The age was 39 (28-46) years, duration

SUBMITTER: Munoz-Hernandez L 

PROVIDER: S-EPMC12703045 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature