Stimulation of High-Conductivity Points in Human Skin Reduces Biotin Levels to Modulate Intracellular Metabolism and Local Energy Production.

ABSTRACT:

Background and aims

Acupuncture is a widely used therapeutic practice that targets specific points on or beneath the skin, known as acupoints. While acupoints are thought to exhibit low electrical resistance, their underlying biophysical and molecular characteristics remain incompletely understood. This study investigates the presence and properties of high-conductivity regions in surgically isolated human skin.

Methods

High-conductivity points (HCPs) were identified on human skin explants using a clinical conductivity-based acupoint detector. Histological, transcriptomic, and metabolomic analyses were performed on HCP and control regions, with and without needle stimulation. To probe mechanistic pathways, human keratinocytes and fibroblasts were cultured under biotin-defici

SUBMITTER: Takagaki K 

PROVIDER: S-EPMC12703051 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature