Beyond the Autoimmune Spectrum, Evaluating Ovarian Health in Systemic Lupus Erythematosus Patients: A Case-Control Study.

ABSTRACT:

Background and aims

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, and recent findings reveal that fertility and ovarian reserve are reduced even in moderate illness, showing that SLE has a direct impact on ovarian function. Therefore, this study aimed to evaluate ovarian reserve using Anti-Müllerian hormone (AMH) and antral follicle count (AFC) in SLE patients compared to healthy controls.

Methods

This case-control study was performed on 300 cases (150 SLE patients and 150 healthy controls). For evaluating ovarian reserve, AMH and AFC were evaluated. Furthermore, SLE activity was determined through the employment of the SLEDAI-2k questionnaire.

Results

Findings revealed that the mean serum levels of AMH were significantly lower in the SLE group a

SUBMITTER: Alamdarloo SM 

PROVIDER: S-EPMC12703120 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature