Vagus Nerve Stimulation in Autoimmune Conditions: A Systematic Review.

ABSTRACT:

Objective

Systemic autoimmune conditions are characterized by increased inflammation and high disease burden. Vagus nerve stimulation (VNS) is known to activate the cholinergic anti-inflammatory pathway and can serve as a potential therapeutic modality for autoimmune conditions. This study aimed to conduct a preregistered systematic review to determine the effect of VNS on inflammation in autoimmune conditions, according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.

Methods

The databases of Medline/PubMed, Web of Science, Scopus, and CENTRAL were searched until September 2, 2024. Data pertaining to changes in inflammatory blood biomarkers and clinical outcomes in patients with autoimmune conditions receiving VNS were extracted. St

SUBMITTER: Lombo LE 

PROVIDER: S-EPMC12703127 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature