Genotype and Haplotype Analysis Between <i>ESR1</i> Variants and Breast Cancer in the Bangladeshi Patients: A PCR-RFLP-Based Genetic Association Study.

ABSTRACT:

Background and aims

Breast cancer (BC) is the most often diagnosed malignancy in women. The genetic factor is estimated to be responsible for the higher BC risk. BC development is thought to be closely linked to the ESR1 gene, which controls cell division and proliferation. Nevertheless, no research has been performed to investigate the relationship between this gene and Bangladeshi women's BC risk. Therefore, this case-control study attempted to determine the association between ESR1 polymorphisms and breast cancer susceptibility.

Methods

This study genotyped two ESR1 genetic variants (rs2234693 and rs9340799) in a total of 399 participants (201 cases and 198 controls) by applying the PCR-RFLP method. SPSS software (v25.0) was used for statistical analysis, an

SUBMITTER: Hossen MS 

PROVIDER: S-EPMC12703133 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature