The lncRNA MYRACL regulates human oligodendrocyte maturation and myelination.

ABSTRACT: Recent studies have described disease-associated expression patterns of long non-coding RNAs (lncRNAs) associated with neurodevelopment and neurodegeneration, highlighting their potential as regulators of function and therefore potential therapeutic targets. Oligodendrocyte (OL) dysfunction drives central nervous system myelin disruption in neurological disorders, but the mechanisms underlying impaired myelin patterns are still poorly understood. In this study, we uncover a role for the lncRNA MYRACL (myelination regulating oligodendrocyte-associated lncRNA) as a regulator of functional maturation and OL myelination. Analysis of RNA-sequencing data performed in human postmortem brain tissue revealed MYRACL to be among the top enriched genes expressed in the OL population compared to the OL

SUBMITTER: Tsarouchas TM 

PROVIDER: S-EPMC12703153 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature