Cardiometabolic multimorbidity in relation to the metabolic score for insulin resistance and creatinine-to-cystatin C ratio in a middle-aged and aged population.

ABSTRACT:

Objective

With the aging population, cardiometabolic multimorbidity (CMM) has become a major public health concern, increasing disease burden and impairing quality of life. The metabolic score for insulin resistance (METS-IR) and creatinine-to-cystatin C (CCR) are promising biomarkers linked to metabolic dysfunction and muscle-renal status, respectively. However, their combined effects on cardiometabolic multimorbidity (CMM), especially in both community and hospitalized populations, remain unclear. This study aims to explore the associations of METS-IR, CCR, and 1/CCR×METS-IR (MRII) with CMM using data from the China Health and Retirement Longitudinal Study (CHARLS) and clinical sources.

Research design and methods

This cross-sectional study included 10,811 participants fro

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12703203 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature