Pericyte drives the formation of circulating tumour cell-neutrophil clusters to promote colorectal cancer metastasis.

ABSTRACT:

Background

Circulating tumour cell (CTC)-neutrophil clusters represent a key driver and a hallmark of tumour metastasis; however, efficient approaches for their elimination are still lacking.

Objective

This study sought to elucidate the location and mechanisms of CTC-neutrophil cluster formation and develop more effective antimetastasis strategies.

Design

Immunofluorescence staining of clinical colorectal cancer (CRC) samples was performed to identify the location of CTC-neutrophil clusters. The correlation between the expression of nicotinamide N-methyltransferase (NNMT) in pericytes and patient prognosis, as well as its association with CTC-neutrophil cluster formation, was assessed using clinical specimens and public CRC datasets. The formation process of CTC-neutr

SUBMITTER: Wang S 

PROVIDER: S-EPMC12703295 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature