Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies.

ABSTRACT:

Background

Acute-on-chronic liver failure (ACLF) of various aetiologies is a complex syndrome with high short-term mortality and significant global burden.

Objective

To explore easily applicable diagnostic criteria and an accurate prognostic score for ACLF.

Design

Clinical data from 5288 patients (after exclusions from 7388 screened) with acute deterioration of chronic liver disease across various aetiologies were used to evaluate the performance of European Chronic Liver Failure (CLIF) and Chinese Group on the Study of Severe Hepatitis B (COSSH) criteria. Three non-Asian cohorts were performed to validate the results.

Results

CLIF criteria categorised 844 patients as ACLF (28-day/90-day liver transplantation (LT)-free mortality: 40.7%/57.0%; 321 with non-hepat

SUBMITTER: Luo J 

PROVIDER: S-EPMC12703309 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature