Functional connectivity between the uncinate fasciculus and frontotemporal semantic system supports reading comprehension in adolescents.

ABSTRACT: Skilled reading arises from the coordinated activity of neural systems supporting word recognition, semantic processing, and executive control. While the structural architecture of white matter tracts involved in reading is well characterized, their functional contributions remain unclear. Here, we examined whether resting-state functional connectivity of the left uncinate fasciculus, a ventral frontal-temporal white matter tract implicated in semantic processing, modulates the relationship between word recognition and reading comprehension. Fifty-three participants (ages 10-14 years; 29 girls, 24 boys) completed resting-state functional MRI and standardized assessments of word recognition and reading comprehension. Functional connectivity between the left uncinate fasciculus and structura

SUBMITTER: Nguyen TQ 

PROVIDER: S-EPMC12703377 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature