Endometrial carcinoma and immune escape: prognostic relevance of HLA class I loss in NSMP subtype.

ABSTRACT:

Aims

This study aims to define and characterize human leukocyte antigen class I (HLA-I) expression in a consecutive series of molecularly classified endometrial carcinomas (ECs), and to evaluate its association with clinicopathologic features, spatial cancer-immune phenotypes and patient prognosis, with a focus on the NSMP (no specific molecular profile) subtype.

Methods and results

HLA-I expression was assessed by immunohistochemistry on whole tissue sections from 208 ECs, classified into POLE-mutated, MMR-deficient (MMRd), p53-abnormal (p53abn) and NSMP subtypes. Loss of HLA-I was identified in 31% of cases and was associated with adverse features including high-grade, aggressive histotypes, deep myometrial invasion, substantial lymphovascular space invasion (LVSI), extens

SUBMITTER: Grillini M 

PROVIDER: S-EPMC12703446 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature