SαKlotho protein is a useful biomarker and a promising cardioprotective agent in acute heart failure.

ABSTRACT:

Introduction

Acute heart failure (AHF) is a heterogeneous and etiologically complex syndrome with a poor prognosis. sαKlotho (sαKL) is an antiaging protein with pleiotropic actions. The aim of this study was to assess the level and kinetics of sαKl during an episode of AHF and its long-term prognostic utility in a population of AHF patients.

Material and methods

It was a prospective multicenter study, which enrolled 133 participants. 112 consecutive patients were admitted to the intensive cardiac care unit with a diagnosis of AHF (age 68 [IQR: 60-75] years, ejection fraction 30% [IQR: 20-38], new-onset AHF 46% of the population). Twenty-one individuals formed the control group. sαKl, N-terminal pro-B-type natriuretic peptide (NT-proBNP) were determined in serum at admission

SUBMITTER: Plonka J 

PROVIDER: S-EPMC12703584 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature