Causal associations of circulating inflammatory proteins with sepsis: a two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Sepsis arises from dysregulated inflammation in response to infection, precipitating organ dysfunction. Circulating inflammatory mediators likely contribute to sepsis pathogenesis, but their precise roles remain unclear. We aimed to evaluate potential causal impacts of inflammatory proteins on sepsis risk.

Material and methods

We performed a two-sample Mendelian randomization study evaluating causal associations for 91 inflammatory proteins with sepsis risk. Genetic instruments were derived from a published genome-wide association study of plasma proteins. Sepsis outcome data were obtained from the UK Biobank and FinnGen cohort. Inverse-variance weighted analysis was conducted along with several sensitivity analyses.

Results

The analyses identified signif

SUBMITTER: Ji D 

PROVIDER: S-EPMC12703588 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature