Association between inflammatory cytokines and prostate cancer: a bidirectional Mendelian randomization study.

ABSTRACT:

Introduction

We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between 91 inflammatory cytokines and prostate cancer (PCa).

Material and methods

The inverse variance weighted (IVW) model served as the primary two-sample MR analysis method, utilized to estimate the causal effect of exposure on the outcome. The weighted median (WM) and MR Egger methods were additionally employed to complement the IVW model. Sensitivity analyses were performed using Cochran's Q test for both the IVW and MR Egger methods. To assess the presence of horizontal pleiotropy, the instrumental variables (IVs) were subjected to the MR-Egger intercept test.

Results

Following Bonferroni correction, the IVW analysis revealed positive

SUBMITTER: Li S 

PROVIDER: S-EPMC12703592 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature