A multi-stage genomic approach to uncover druggable gene targets and neural pathways in postpartum depression.

ABSTRACT:

Introduction

Postpartum depression (PPD) is a severe emotional disorder affecting women worldwide, with significant impacts on maternal and infant health. Its genetic contributors and biological mechanisms are poorly understood. Identifying druggable genes and clarifying their causal roles may offer insights for developing more effective treatments.

Material and methods

We identified drug-related genes and screened gene expression quantitative trait loci (eQTL) from the eQTLGen consortium and genotype tissue expression (GTEx) v8 dataset, focusing on 13 brain tissues, along with Qi et al.'s meta-study on the cerebral cortex. Mendelian randomization (MR) analyses were used to investigate causal relationships between gene expression and PPD risk. Replication analyses in

SUBMITTER: Li CY 

PROVIDER: S-EPMC12703596 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature