Genetic causal relationship between physical activity and osteoarthritis: a two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Appropriate levels of physical activity (PA) can help prevent osteoarthritis (OA) and alleviate its symptoms. However, excessive or prolonged PA has been identified as a potential risk factor for OA. Despite these observations, the genetic causal relationship between PA and OA remains unclear. Therefore, this study aimed to clarify the causal link between PA and OA by investigating their shared genetic factors.

Material and methods

The study utilized genome-wide association study (GWAS) summary data to investigate the relationship between three types of PA - moderate to vigorous physical activity (MVPA), vigorous physical activity (VPA) and strenuous sports or other exercises (SSOE) - and knee osteoarthritis (KOA). A two-sample Mendelian randomization (MR) analy

SUBMITTER: Yang M 

PROVIDER: S-EPMC12703599 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature