Whole-body water mass and osteoarthritis: a Mendelian randomization study.

ABSTRACT:

Introduction

This study aimed to elucidate the potential impact of whole-body water mass on osteoarthritis at the genetic prediction level through a two-sample Mendelian randomization (MR) analysis.

Material and methods

Using summary data from genome-wide association studies, we obtained information on whole-body water mass and various forms of osteoarthritis, including knee and hip osteoarthritis, knee osteoarthritis, and hip osteoarthritis from a large-scale genome-wide association study. MR analysis used inverse variance weighting, weighted median, MR-Egger, simple mode, and weighted estimation. Sensitivity analyses, including the MR-Egger method, MR-PRESSO, Cochran's Q-test, and leave-one-out assessment, were performed to assess the reliability of the results.

Results

SUBMITTER: Qu Q 

PROVIDER: S-EPMC12703614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature