Aryne Generation from Aryl Halides Via Photothermal Red-Light Activation.

ABSTRACT: Multistep synthetic methods requiring harsh conditions and poor atom economy are central to the generation of aryne precursors. The Kobayashi method remains the standard for aryne generation, and newer methods have relied on similar strategies for activated precursors for mild aryne generation. Here, we show the generation of arynes from commercially available aryl or heteroaryl halides via photothermal conversion in air using red light. With photothermal conversion, a high-energy aryne intermediate is formed via inhomogeneous thermal gradients. Nitrogen nucleophiles then readily trap the aryne intermediate to forge C-N bonds, an essential bond in pharmaceutical and agrochemical synthesis, simplifying traditional methods that use aryl halides as aryne precursors. A wide range of readily av

SUBMITTER: Preston-Herrera C 

PROVIDER: S-EPMC12703699 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature