Causal Relationship Between Circulating Omega-3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study.

ABSTRACT: Cerebral small vessel disease (CSVD) plays an important role in the onset of stroke and cognitive dysfunction. Its primary imaging manifestations encompass lacunar stroke (LS), white matter hyperintensity (WMH), white matter perivascular space (WMPVS), and cerebral microbleed (CMB). While omega-3 fatty acid (FA) has shown potential protective effects against vascular diseases, their causal role in CSVD remains unclear. This study aims to investigate the causal relationship between circulating Omega-3 FA levels and various CSVD phenotypes using Mendelian randomization (MR). Data on circulating omega-3 FA levels were derived from a large genome-wide association study (GWAS) summary dataset comprising 115,060 individuals. Data on CSVD phenotypes were obtained from several large GWAS datasets,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12703811 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature