History of Breastfeeding in Relation to Circulating Inflammatory and Metabolic Biomarkers.

ABSTRACT:

Background

Breastfeeding history has been associated with reduced risk of chronic diseases, although the underlying biological link is unclear.

Methods

The study included 16,165 parous women in the Nurses' Health Studies who reported lactation history and biomarkers measured using plasma samples collected at midlife. We calculated multivariable-adjusted geometric means of 10 inflammatory biomarkers [high-sensitivity C-reactive protein, IL6, IL8, IL10, insulin-like growth factor 1 (IGF1), soluble TNFα receptor 2, B cell-activating factor, C-X-C motif chemokine ligand 13, soluble IL2 receptor α, and soluble IL6 receptor-α] and eight metabolic biomarkers (triglyceride, total cholesterol, high- and low-density lipoprotein, leptin, soluble leptin receptor, adiponectin, and retino

SUBMITTER: Lin N 

PROVIDER: S-EPMC12703830 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature