Early lymph node T follicular helper cell signalling hub drives influenza vaccine response in an ancestrally diverse cohort.

ABSTRACT:

Background

Early in vivo dynamics of human immune-cell activation across regionally activated lymphoid tissue sites upon immunisation are poorly characterised in ancestrally-diverse individuals with consequences for pandemic preparedness.

Methods

In this experimental medicine study, draining and non-draining lymph nodes (dLNs and ndLNs) were studied by ultrasound (US)-guided fine-needle aspiration (FNA) in 13 adults aged 18-55 years with African and Asian ancestry, before and after receiving adjuvanted seasonal influenza vaccine (aQIV). A multi-modal investigation of ultrasound data, genotyping, systems serology, and single-cell multi-omics was undertaken.

Findings

HLA subtypes reflected self-declared ethnicity and included understudied alleles. Draining but not ndLNs

SUBMITTER: Siu JHY 

PROVIDER: S-EPMC12703867 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature