Methodological comparison between salivary and plasma inflammatory biomarkers in third molar surgery patients.

ABSTRACT:

Background

Changes in saliva biomarkers levels may be an inflammatory response to local surgical trauma or other threats. The aim of the study was to compare saliva and plasma regarding the expression of a large set of inflammatory biomarkers to find clinically useful biomarkers in saliva.

Methods

Both saliva and blood samples were collected from 165 individuals. For every patient, the samples were collected on the same occasion. Saliva and plasma protein levels were analysed using the OLINK Proseek inflammation panel measuring 92 cytokines, chemokines, and growth factors (CCGF). The levels of individual CCGF were compared between saliva and plasma. A Spearman rank test was used to find correlations (r_s).

Results

Of the 92 inflammatory biomarkers, 71 were d

SUBMITTER: Eriksson LB 

PROVIDER: S-EPMC12703913 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature