The underperforming Abbott-Bioline Malaria Ag P.f/P.v rapid diagnostic test: a whiter shade of pale - where the truth is not plain to see.

ABSTRACT: The Abbott-Bioline™ malaria antigen Plasmodium falciparum and Plasmodium vivax rapid diagnostic test (Abbott-Bioline™ Malaria Ag P.f/P.v RDT) is used widely in the Greater Mekong Subregion. It is approved by the World Health Organization (WHO) and deployed on a large scale in the regional malaria elimination programmes. Following reports of false-negative test results from field-workers, the Abbott-Bioline™ Malaria Ag P.f/P.v RDT was compared with microscopy in 187 persons with fever during a vivax malaria outbreak in Myanmar. Among them 11 tested positive for P. vivax using the Abbott RDT, while 46 were diagnosed with P. vivax malaria by microscopy. The sensitivity of the Abbott RDTs among febrile patients was 0.24 (95% CI 0.12-0.36) with a specificity of 1.0. Twenty-eight (61%) of the 46

SUBMITTER: Thein KS 

PROVIDER: S-EPMC12703916 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature