Sex Hormone Androgen Elevates Blood Pressure Through Gut Microbiota-TMAO Pathway.

ABSTRACT:

Background

Hypertension is a leading risk factor for all-cause mortality worldwide, affecting ≈1.3 billion people. Imbalanced gut microbiota contributes to blood pressure elevation. We recently reported sex differences in the responses of gut microbiota to environmental stimuli, such as salt, with male gut microbiota being more vulnerable to induce high blood pressure than female microbiota. In this study, we investigated the mechanisms by which gut microbiota regulate blood pressure in a sex-dependent manner.

Methods

Antibiotic treatment, gonadectomy, sex hormone replenishment, and treatment with trimethylamine N-oxide or its blocker were performed in male and female spontaneously hypertensive rats.

Results

We observed sex differences in gut microbiota composition an

SUBMITTER: Li Y 

PROVIDER: S-EPMC12703944 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature