Standardized Residue Numbering and Secondary Structure Nomenclature in the Class D β-Lactamases.

ABSTRACT: Over 1370 class D β-lactamases are currently known, and they pose a serious threat to the effective treatment of many infectious diseases, particularly in some pathogenic bacteria where evolving carbapenemase activity has been reported. Detailed understanding of their molecular biology, enzymology, and structural biology are critically important, but the lack of a standardized residue numbering scheme and inconsistent secondary structure annotation has made comparative analyses sometimes difficult and cumbersome. Compounding this, in the post-AlphaFold world where we currently find ourselves, an extraordinary wealth of detailed structural information on these enzymes is literally at our fingertips; therefore it is vitally important that a standard numbering system is in place to facilitate

SUBMITTER: Stasyuk A 

PROVIDER: S-EPMC12703946 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature