Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating respiratory disease with limited therapeutic options. Genetic association studies for IPF have identified several associations and probable effector genes that could not only help understanding IPF pathogenesis but also develop effective treatments. Assessing genetic overlap between IPF and severe COVID-19, an acute respiratory disease that can trigger pulmonary fibrosis, may reveal shared aetiology and mechanisms, thereby supporting the development of common treatments.

Methods

We carried out genome-wide association studies (GWAS), post-GWAS, and rare variant analyses using whole genome sequencing data from the 100,000 Genomes Project IPF cohort (n = 586). We performed a meta-analysis combining

SUBMITTER: Kousathanas A 

PROVIDER: S-EPMC12703957 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature