Commensal <i>Staphylococci</i> attenuate <i>Staphylococcus aureus</i> skin colonization and inflammation via AHR-dependent signaling.

ABSTRACT:

Introduction

Staphylococcus aureus is the leading cause of bacterial skin infections in several inflammatory skin diseases, however, is rarely detected on healthy skin. Skin barrier defects, such as in atopic dermatitis, promote S. aureus colonization by yet unknown mechanism. In our previous work we found that in healthy skin commensal staphylococci including Staphylococcus epidermidis and Staphylococcus lugdunensis (SL) protect against S. aureus skin colonization, however, the microbiome-mediated protection is lost in inflammatory skin. Here, we investigated how microbiome-derived factors contribute to skin defense under homeostatic and inflammatory conditions.

Methods

We examined how bacterial conditioned media (BCM) from S. epidermidis and

SUBMITTER: Riebelmann J 

PROVIDER: S-EPMC12703969 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature