Microglia Display Altered Spatial Morphology and Proteome After Stroke.

ABSTRACT: Microglia are abundantly distributed throughout the central nervous system (CNS) to play critical roles in neural development and homeostasis, and act as immune sentinels to constantly monitor their surrounding neural environment. Given their high reactivity to brain insults, we hypothesised that the cerebral microenvironment altered by ischaemic stroke would significantly impact microglial morphology and function in a spatially dependent manner. To investigate this, we examined regional gene expression changes associated with microglial activation and neuroinflammation, microglial morphology using 3D image reconstruction and unbiased proteomics at 24 h after transient middle cerebral artery occlusion (tMCAO). We found the microenvironment within the ischaemic infarct core has a distinct p

SUBMITTER: Wanrooy BJ 

PROVIDER: S-EPMC12704032 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature