EXO/hydrogel system for sequential regulation of endogenous hyaline cartilage regeneration.

ABSTRACT: Articular cartilage repair remains a clinically significant challenge due to its limited regenerative capacity and vulnerability to inflammation-induced damage and fibrocartilage formation. Current therapeutic strategies frequently fail to enhance intrinsic repair capacity or overcome the dual barriers of injury/inflammation-driven fibrosis and insufficient hyaline cartilage regeneration, often yielding suboptimal outcomes. Here, we developed an exosome-integrated hydrogel system for temporally programmed drug delivery. Kartogenin (KGN) and halofuginone (HF) were encapsulated into human umbilical cord MSC-derived exosomes (EXO_KGN/EXO_HF). EXO_HF was specifically immobilized in GelMA hydrogel via CP05-CD63 binding, while EXO_KGN was incorporated unbo

SUBMITTER: Wu K 

PROVIDER: S-EPMC12704077 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature