Acute effects of a single session of multitarget continuous Theta-Burst stimulation for essential Tremor: A Randomized, Sham-Controlled trial.

ABSTRACT:

Background

Current treatments for essential tremor (ET) are suboptimal. This study aims to assess the safety and acute effects of a single session, multitarget continuous theta-burst stimulation (cTBS) applied to the bilateral primary motor cortex (M1) and cerebellum in ET patients, and to explore the underlying mechanisms.

Methods

ET patients were randomly allocated to either the cTBS group (n = 30, 80 % action motor threshold (AMT)) or the control group (n = 30, sham treatment). The primary outcome was tremor severity, assessed using the Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS), encompassing part A, B, C and total scores at baseline and 0, 10, and 45 min post-intervention. The secondary outcomes included detailed FTM-TRS subscores (specifically midline tremor [MT] a

SUBMITTER: Luo A 

PROVIDER: S-EPMC12704090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature