Intensive blood pressure reduction but an increased risk of peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

To assess the association between the blood pressure (BP) reduction mediated by BP-lowering agents and the risks of peripheral arterial disease (PAD) in patients with cardiometabolic risk factors.

Methods

PubMed, EMBASE, the Cochrane Centre Register of Controlled Trials for Studies, the Scopus, Web of Science and Clinicaltrial.gov were searched from January 1980 to October 2023. Randomized controlled trials (RCTs) with statistically significant BP reduction in intensive BP-lowering treatments group compared with control treatment group, reporting the incidence of PAD were included. Regular and dose-response meta-analyses were both conducted.

Results

In all, 15 RCTs involving 94482 participants were included. The standardized analysis based on systolic blood

SUBMITTER: Jiao R 

PROVIDER: S-EPMC12704138 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature