Exosome-Associated MTA1 in Circulation Is Elevated During Breast Cancer Progression.

ABSTRACT: Metastasis-associated protein 1 (MTA1) is overexpressed in breast cancer cells, and the MTA1 expression level is correlated with the metastasis and progression of breast cancer. We recently reported that MTA1 is transferred via exosomes from breast cancer cells to adjacent cells and to the circulation of breast cancer patients. However, whether exosome-associated MTA1 may serve as an indicator of breast cancer progression remains unknown. Wild-type MDA-MB-231 cells, MDA-MB-231 cells with MTA1 knockout, and human stromal cells were used to confirm MTA1 transfer via exosomes. Plasma was collected from nude mice (n = 6) implanted with MDA-MB-231 cells or MTA1-knockout MDA-MB-231 cells. Serum from patients with breast cancer (n = 59) and age- and sex-matched healthy subjects was collected. Exo

SUBMITTER: Bhandari K 

PROVIDER: S-EPMC12704216 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature