Effect of Antimicrobial Divalent Metal Cations Onto Oxidized Surface of Polyhydroxyalkanoate Films on Biodegradability in Seawater.

ABSTRACT: Poly[(R)-3-hydroxybutyrare-co-(R)-3-hydroxypivalate] (P(3HB-co-3HPi)) films, a type of polyhydroxyalkanoate (PHA), are oxidized using photoactivated chlorine dioxide radical (ClO₂•) gas to generate carboxyl groups and loaded with divalent metal cations, including Cu²⁺, Zn²⁺, and Ca²⁺ ions, via ionic interactions. The P(3HB-co-3HPi) films loaded with Cu²⁺ ions exhibit enhanced antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) compared with untreated P(3HB-co-3HPi) films. In seawater, the biodegradation of these Cu²⁺ and Zn²⁺-loaded films is initially inhibited by the antimicrobial activity of the cations and occurs gradually; therefore, loadi

SUBMITTER: Tateiwa J 

PROVIDER: S-EPMC12704234 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature