Injectable Self-Polymerizing Hydrogel as Bone Filler for Bone Defect Treatment.

ABSTRACT: Poly(methylemethacrylate) (PMMA) bone cement treats bone defects that have a sol-gel behavior that allows injection application. However, it raises concerns such as leakage, toxicity, infection, and incompatible porous structure. Here, we report an injectable gel catalyzed by silver nanoparticles (AgNPs), allowing highly efficient and biocompatible in situ polymerization to fill up the defects and eliminate infection. This gel consists of gelatin methacryloyl (GelMA) and methacrylated chitosan (ChiMA), providing a similarity to the extracellular matrix for improved cell growth, where mussel-inspired polydopamine (PDA), reduced nano silver can be a catalyst for free radical polymerization due to its high electron activity. We further found the high surface/volume ratio of micro hydroxyapati

SUBMITTER: Wu X 

PROVIDER: S-EPMC12704240 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature