Human urine-derived stem cells rescue cutaneous manifestation and suppress inflammation and fibrosis <i>in vitro</i> and in a mouse model of recessive dystrophic epidermolysis bullosa.

ABSTRACT:

Background

Recessive dystrophic epidermolysis bullosa (RDEB) is a life-threatening disease characterized by persistent wound inflammation, tissue fibrosis, and even tumorigenesis in later stages. Despite its significant impact on patient health worldwide, treatment of RDEB has limited options. There is a clear need for now interventions. The goal of this study was to explore the potential efficacy of urine-derived stem cells (USCs) in RDEB.

Methods

We isolated human USCs from healthy donors, and assessed their therapeutic effects on RDEB both in vitro with tissue-engineered skin in a three-dimensional co-culture system and in vivo with COL7A1 ^-/- (RDEB) mice.

Results

USCs showed suppressive effects on expression of inflammation- and fib

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12704442 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature