Real-World Molecular Testing in European Early-Onset Colorectal Cancer.

ABSTRACT:

Purpose

The global incidence and mortality of early-age onset colorectal cancer (EOCRC, or CRC diagnosed under 50 years) has increased in recent decades. High-risk surveillance and personalised oncological treatment may improve patients' outcomes. This study aims to characterise real-world somatic and germline molecular profiles in European EOCRC patients.

Patients and methods

Consecutive patients across the UK, Spain, Germany and Italy from the GEOCODE and SECOC consortia were identified using electronic patient records. Clinicopathological, somatic and germline testing data were collected on EOCRC patients. Tests included mismatch repair (MMR), somatic next generation sequencing (NGS) and germline multi-gene panels.

Results

Eight hundred ninety-three EOCRC patients

SUBMITTER: Edwards PV 

PROVIDER: S-EPMC12704576 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature