Tri-layer structured intelligent hydrogel dressing for controlled-release antibacterial treatment of chronic diabetic wounds.

ABSTRACT: Chronic diabetic wounds are notoriously difficult to heal due to a hyperglycemic environment, persistent oxidative stress, and infection, leading to slow healing and frequent complications. In this study, we developed a tri-layer intelligent hydrogel dressing for diabetic wound care. The top layer contains silver nanoparticles (AgNPs) for rapid initial antibacterial action. The middle layer incorporates poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with mangiferin to achieve sustained drug release and promote angiogenesis. The bottom layer is a gelatin methacryloyl (GelMA) hydrogel scaffold that provides structural support. The composite materials' morphology and structure were characterized by scanning and transmission electron microscopy (SEM, TEM). We evaluated the pro

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12704595 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature