Local genetic correlation analysis of Alzheimer's disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestry.

ABSTRACT:

Background

Neuropathological studies indicate a strong association between Alzheimer's disease (AD) and stroke, yet the molecular mechanisms underlying this association remain unclear.

Methods

Local genetic correlation analysis was conducted with LAVA using the results from genome-wide association studies on AD and stroke in individuals of African ancestry. Enhanced Hi-C Capture Analysis (eHiCA) examined chromatin interactions using iPSC-derived cells from AD brain autopsy samples.

Results

LAVA identified a region shared between AD and stroke on chromosome 18q21.33(r _g = .77, P = 2.41×10^-6). eHiCA demonstrated that the AD and stroke loci interact with regulatory elements in PHLPP1. Variants at PHLPP1 were also a

SUBMITTER: Ray NR 

PROVIDER: S-EPMC12704622 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature