<i>APOE</i>*4 Risk-Modifying Genes and Drug Targets in Alzheimer's Disease through Cell-Type Specific Genomic Analyses.

ABSTRACT:

Importance

APOE*4 is the strongest, common genetic risk factor for late-onset Alzheimer's disease (AD) with widespread and cell-type-specific impact on disease pathogenesis. Genetics and omics studies can help identify genes that counteract the effects of APOE*4, but so far have remained relatively small and crucially did not assess genetic findings through a cell-type-specific framework.

Objectives

Perform a large-scale APOE*4 stratified genome-wide association study (GWAS) of AD integrated with genetically tethered cell-type-specific multi-omics data.

Design

Meta-analysis of APOE*4 stratified AD GWAS in case-control, family-based, population-based, and longitudinal AD-related cohorts from the Alzheimer's Disease Genetics Consortium, Alzhe

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC12704626 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature