Shared genetic architecture between anorexia nervosa and metabolomic biomarkers suggest underlying causal pathways.

ABSTRACT:

Background

Anorexia Nervosa (AN) has a high mortality rate and often a chronic illness course, yet few existing treatments are effective. AN is heritable and shares genetic architecture with cardiometabolic traits, while the relationship to metabolomic markers is unknown.

Methods

We analyzed genome-wide association studies (GWAS) of 249 circulating plasma metabolomic biomarkers and AN to map their shared genetic architecture and compare with related mental health, anthropometric and cardiometabolic traits. We leveraged multiple methods to estimate genetic overlap, including global genetic correlations with linkage disequilibrium score regression, conjunctional false discovery rate, and bivariate Gaussian mixture modeling. We mapped shared genetic variants to genes and biolog

SUBMITTER: Makowski C 

PROVIDER: S-EPMC12704635 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature