Disproportionately Elevated Sulcal Index (DESI): An automatically driven index representing disproportionate subarachnoid space enlargement in brain MRI scans.

ABSTRACT:

Background

Idiopathic normal pressure hydrocephalus (iNPH) is a reversible cause of dementia in older adults yet remains underdiagnosed due to nonspecific clinical presentation and reliance on invasive confirmatory tests. Conventional MRI biomarkers, including the Evans index and callosal angle, capture ventricular enlargement but incompletely characterize cerebrospinal fluid (CSF) redistribution. Disproportionately enlarged subarachnoid-space hydrocephalus (DESH) features, tight high-convexity sulci and enlarged Sylvian fissures, are more disease-specific but lack standardized quantitative measures.

Methods

We developed the Disproportionately Elevated Sulcal Index (DESI), an automated volumetric biomarker quantifying the ratio of Sylvian fissure volume to superior sulcal sp

SUBMITTER: Barough SS 

PROVIDER: S-EPMC12704640 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature