Genetic Liability for Internalizing-Externalizing Traits in Mexican Youth: Moderation by Adversity.

ABSTRACT:

Objective

We examined whether common and specific genetic liabilities for internalized (INT) and externalized (EXT) traits predict corresponding disorders in Mexican youth, and whether adversity moderates these associations.

Methods

Participants were 1,130 Mexican adolescents (ages 12-17; 54.9% female). Psychiatric diagnoses and adversities were assessed using the World Mental Health Composite International Diagnostic Interview for Adolescents. Genome-wide association summary statistics for 12 INT and EXT traits were analyzed using genomic structural equation modeling (SEM) to derive polygenic scores (PGS) from latent genetic factors. Associations were tested using multinomial logistic regression.

Results

The best-fitting genomic SEM bifactor model included one shared

SUBMITTER: Ceja Z 

PROVIDER: S-EPMC12704648 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature