Accuracy of electronic medical records to quantify rates of sedative and analgesic infusions for acute disorders of consciousness big data research.

ABSTRACT:

Background/objective

The reliability of electronic medical records (EMR) for exposure to sedative and analgesic medications in patients with acute disorders of consciousness is unknown. Our objective was to quantify the accuracy of sedative and analgesic infusion rates derived from the EMR to support its use in big data clinical research.

Methods

We conducted a prospective cohort study enrolling critically ill patients who were unresponsive to verbal commands after acute brain injury. During standardized behavioral assessments, research coordinators documented infusing sedative and analgesic medications in case report forms (CRF; reference standard). We extracted infusion rates from the EMR (index) and calculated concordance correlation coefficients for drugs with ≥ 10 EMR-C

SUBMITTER: Briard JN 

PROVIDER: S-EPMC12704649 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature