Cannabis use and psychotic-like experiences in the <i>All of Us</i> Research Program.

ABSTRACT:

Background and hypothesis

Cannabis use has been linked to psychotic-like experiences (PLEs). Amid increasing legalization, we examined the extent to which cannabis use is associated with PLEs after adjusting for other risk factors in a contemporary United States sample.

Study design

We performed a cross-sectional analysis of self-reported cannabis use and four types of self-reported PLEs (auditory and visual perceptual distortions, referential ideation, and persecutory ideation) in the population-based biobank, the All of Us Research Program release 8 (maximum analytic N = 62,153).

Study results

Cannabis ever-use (ORs = 1.21 - 1.44, p-values < 2.7e-6) and more frequent past 3-month cannabis use (within lifetime ever-users) were associated with all four PLEs (χ<

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC12704650 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature