Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.

ABSTRACT: Higher exercise capacity and regular exercise training improve cancer prognosis at all stages of disease. However, the metabolic adaptations to aerobic exercise training that mediate tumor-host interactions are poorly understood. Here, we demonstrate that voluntary wheel running slows tumor growth and repartitions glucose uptake and oxidation to skeletal and cardiac muscle and away from breast and melanoma tumors in mice. Further, prehabilitation induces repartitioning of glucose metabolism in obese mice: Uptake and oxidation of glucose are enhanced in skeletal and cardiac muscle, and reduced in tumors. These increases in muscle glucose metabolism and reductions in tumor glucose metabolism, correlated with slower tumor progression. Using [U-¹³C₆] glucose infusion, we

SUBMITTER: Leitner BP 

PROVIDER: S-EPMC12704748 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature