Functional and structural impacts of oncogenic missense variants on human polo-like kinase 1 protein.

ABSTRACT:

Introduction

The polo-like kinase 1 (PLK1), a master key mitotic regulator, is frequently expressed in various types of cancers and associated with poor prognosis. The missense mutations in PLK1 may compromise its structural integrity and functional interactions, contributing to tumorigenesis.

Methods

This study utilized a comprehensive computational pipeline to identify deleterious missense variants across multiple cancers. 207 non-synonymous single nucleotide polymorphisms (nsSNPs) were retrieved from cBioPortal, and 11 high-risk variants were prioritized using functional and structural prediction tools, such as SIFT, PolyPhen-2, I-mutant 2.0, and so on. Prognostic prevalence was evaluated via Kaplan-Meier survival analysis, and functional networks were explored using STRI

SUBMITTER: Munieswaran G 

PROVIDER: S-EPMC12704984 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature