Risk Factors for Rectal Neuroendocrine Tumors: A Population-Based Cohort Study of Sex-Specific Associations.

ABSTRACT:

Introduction: Risk factors for rectal neuroendocrine tumors (NETs) have rarely been reported in large-scale cohort studies, although previous cross-sectional research has reported some associations. We aimed to clarify the sex-specific contributing factors for rectal NETs.

Methods

We conducted a population-based cohort study, including individuals without previously diagnosed cancer and NETs who underwent national health examinations and cancer screenings in 2010, with follow-up until 2017.

Results

Among 5.521 million, 2,342 patients with rectal NETs were identified. In the adjusted analysis, male sex (adjusted hazard ratio [aHR] 1.27; 95% confidence interval [CI]: 1.12-1.43), current smokers (aHR 1.15), past smokers (aHR 1.16), and obesity (aHR 1.50; 95% CI: 1.03-2.20) we

SUBMITTER: Kim SU 

PROVIDER: S-EPMC12705081 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature