A Systematic Review of Management of Cramping Pain in Patients with Amyotrophic Lateral Sclerosis.

ABSTRACT:

Introduction

Pain, particularly cramping, in people living with amyotrophic lateral sclerosis (ALS) is often underrecognized and under-treated. Despite affecting over 70% of people living with ALS (plwALS), cramping pain remains inadequately managed due to its complex nature and the difficulties plwALS face in communicating their symptoms as the disease progresses. This systematic review explores both pharmacological and non-pharmacological treatments for cramping pain in ALS, aiming to assess and compare their efficacy.

Methods

The systematic review was conducted following PRISMA guidelines, and the protocol was registered with PROSPERO (ID CRD42024521649). A comprehensive search was performed across MEDLINE, Embase, Scopus, and Cochrane databases from inception until Febru

SUBMITTER: Hall HK 

PROVIDER: S-EPMC12705082 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature